Ferman, Nazlı and Ali are going to a conference abroad for a prestigious award. But when Ezo surprises everyone and gets on the same plane, things get messed up from the very beginning. On the other hand, Tanju, who is called to the court, has to entrust the surgical department to Demir and Doruk. When a patient in critical condition is brought to the emergency room, Demir and Doruk have no choice but to act without Tanju knowing. Meanwhile, the passengers on the plane begin to suffer from a mysterious disease. While time is rapidly shrinking, everyone is tested to the end of their limit. And those who come face to face with death will make confessions that will surprise even themselves.